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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d2ed65c63ac4a9b19d4170566227d7e655cd4e689d0cb41682a8283f166d415' 
  AND token = 'IYPF6/PmwTmVMcwEcY/O8b1fz3HcneZOT6iDq3yCvtA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00053

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}