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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '580529ec549e136b1c2a24a153e051e8590678c93bedad1e6f0c2ffdab6a2c85' 
  AND token = 'LNR5P2Lrnsbpev7R7hvMDZM40qagXgSGoP3p56RC1Hw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}