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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8c8b67799a2d210a1021714eeb89add3e067f5b6704c4095dcfc092a58446af' 
  AND token = 'UuArWmoeX1hmi1r0acY/qvy+K+RcHXS2tmh34w7Dc64=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}