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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2997221ce4e0379c761fac19ea820cc6bcc5718920a21d892b767cfed4255f5a' 
  AND token = 'Ko/lEIYSenxWEowcM5Bbk3WxUsrocgmoC7WWO0mNT3s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}