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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2c78caee354fd8a84191456be78fa16afd163a08273c49eb130e93544b54dae' 
  AND token = 'UV0yf+m8+SfVNjBzqQg3hYN7FCUOuUyo7E8ml5rrNOA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}