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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b12cf1bc64ad1cfa416f6442ba3b0961b1aeb62be046f9d8a38f9df40039b61' 
  AND token = 'MyynRRmZMJ+naomHaU9hjw/umEU/JDkESLXFraPEwM4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}