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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '804480f4fff8cf3eccad8e9386d9c83a3baf0d4f4b6a010040d60e83654bf043' 
  AND token = 'XTV11iMty8HpTTuyXm9GeoDKYh5oCyF7x3mqVfCMdDw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}