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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e6678d994f1df71aec03800724d2a6088826508cb2ea6010dd52a7e6dbb3baf' 
  AND token = 'lCLiD0xgrKHS4mZKcGCdeLaC5ZDpAtfu5FUt/iCE8CE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}