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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b3106e22ffd398252396267c6990846c66b9f77216defcfdd99e4c8da9a9e95c' 
  AND token = 'fMNnl+psPENaWBj1GB36xsvqT/RAGB9erWWEZISHQrk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}