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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '40bd78c25549e8221e9414bcb582b82454e93914df4e957bf8dbd01e202d0f8c' 
  AND token = 'lgCncIeGPI2d1s62qcOoq0rrEITCFvHU77Zhdq4DAQ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}