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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '999c42d34e325989add545fd1c5548c24851b0e33f9df7035f3360a5c7e4a2d3' 
  AND token = 'FQmOaQC0M+fm2JeO5FQLR+eoWRy44E1kCe+erXecUXQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}