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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22b1f10100e74a781e083fc246d1e9769baf507772710fa81fcf65ddd7b4062b' 
  AND token = 'qUMIxigyo3PayFLXM+2g5lgweY6MHv71t8Oex/dNLfA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}