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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a63ab36397b33b0da05bb9b2240d81c530ad8feef9c4b52862dc9d46542d9e4' 
  AND token = 'LG4I9HV7XsAf8DpAF3nqw6FMl8aUpeQKbbc0Rh7/0TE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}