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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c916444143b2466dd582e3b17cbc54fba016234dffc18d8cfe15a6fd59b59529' 
  AND token = 'cgPEd8n8YTV3lyV+yAUYpdpfVOe9UKmFCm+OiVp1Z14=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}