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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33cd61c46422018ecefc0b2af940e9b9c33eec153d12394b20e14d62d89e99cf' 
  AND token = '1xJ12sYfcEt/GC+MUAjGSpnKwsMOZaSfVUS2TlAuFsQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}