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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'eca59863b43c8dc66af40d0e14c4b7c460a4e543ccd39c39f202a19f14c87e12' 
  AND token = '50MfI6MCZ2EwxsNr1+Y+gzjlwkUfdS2OdoE8MhHKjGM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}