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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f39e99382e7c4061c2360de7130f858ba9cbe0ac93b2bee44fc678a3e29c960' 
  AND token = '+IjZTp8Vgr5VgDObJY8+B1mDl4EuCNtEUzpCKnMeXm0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}