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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221d58ef2b83e99ae3adb5bc56edb12ed48b5a9649c3cc0ee8e6831601530cbe' 
  AND token = '2OLqISoX48V0UsEmJ36pla0+/K/3xinwS3XexxnazlI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}