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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fa17cc90e18e34193a3e1b2b3845cf6dfe613ed51112b132a3e0555cb6beed21' 
  AND token = 'DoqQfTcxM+jiEXwV/OmkkX4QLR5YT6ou9X6vZzKmdPk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}