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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10b0b2aa2c234ecebc2e3c913ec542d1733429ac915dd8744953b47812c3bff4' 
  AND token = 'F/ETexVf4k+YMoki0gHHRw0I48MU16Y8a+f5kJg2Eng=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}