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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4429621a32660f09e5919e26c71996d376871a6710af73b2dd2073ae8aaacc63' 
  AND token = '6cgX/TPgr8YOdIfOUShRWvgdPR51tID1Zr0lMWDqXVI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}