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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8489efa8a111943863afadea512c570b05e55b8b376a80f56de69dc774d361b2' 
  AND token = 'puY6rrTrtPZFe0FJskKj5WPVNAr3epQdsDnfXQ/WYH4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}