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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '704d6c21c8e72756ce14da300b7ba7bb98d04c34fad7c2bbcc7c788fa74280e6' 
  AND token = 'JXPTmWFm/gm48RD/4TDYIu6d16UbgtBzVgiJSflT8fM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}