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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43b86e45862e28df23adf582729dd335ee1f532281798449d822426dd8bf2180' 
  AND token = '4CG137vcHoaTMBKbJZ0sCN9KgYCMn0imVw2p50Bbgzg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}