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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2645cc2dc66e7ec10a60c0dff169dc0de0c7b108a9f2f83319bf02121da1f380' 
  AND token = 'pzgKH6W/76XiXtXLe3xXMsdYRvqPN6UzB+Ps5HQf2HE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}