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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e00b507a1c3d4604146a75f80516390598e1de54196096192a35b6a93116a0c7' 
  AND token = 'mRK7BhzmyYWUX0xcPrb0P0mLrzJMyfelTMJbgdzbL0U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}