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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a77b20364a5153a9c8aa00b19d0920d7469d40fcd9038cf1b9664d5cebe4e349' 
  AND token = 'PGbSXDYbUhPlnmWcLF3AXVOMYzanWRH6Ifv6cKwWLsE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}