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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d1dc41e4531a4bd791b4e128f6a21954a6278cfd445adcc34dcd69be4f416b' 
  AND token = 'kiRK/1SnzXAtb7StGBdx1G1/M96zCDMmE7iXNnZrxjI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}