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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ec0b01a3c949445f7c219680fb69ef18e49ba44d9a019745dac19f39a1d3436' 
  AND token = '27T6Q1Gr6xBBmewm+5VpgeZR4AuSEkkf3+zs1N98/Wg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}