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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '749eb58835e52f05d34a7f00b14c2671f032bce03762a986f2c3d6c26172f55f' 
  AND token = 'RZqP22fbeg5oG1UTvdes2kQAZq7AdOln4weTj9vFteQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}