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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5d65e9934a8fd8c0dbfd450d153e05dddf0e256a0c64aaf1828ce898251c2175' 
  AND token = 'uz/n4+WTp5+WEzMGUtSnkBoVm+l6emAn4U0tihluaJI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}