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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '539f1f1aefbd14a59f88d62e5d91081671cba317fab03af2a0c3189c443f3551' 
  AND token = 'EOjGbE7lVy+c6EQVWjubBVoda0SnqNbj3H83dTd41As=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}