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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b21c1a1feaeaef017bed59bffa7ba2879b1a8f7b07d8233e33beb22c84279028' 
  AND token = 'tSYwiRaIQm0XLGwWVp2wcN9R9JJGjl8b7NLc5OhiaxY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}