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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ad483d1aaf02a27c63ff67406bf7b7af1507b047fd76a31565522186823a1bd' 
  AND token = '42BiiG7y2MAwaTiFjMpdRZNWplrPeQzuFD7601UPYzs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}