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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a6296d48ee602540945ec3e451201144940054bd678fb99d1a727b5fb80d4986' 
  AND token = 'SEdy1zUJ5vD7BcW7a7CIUqH1liIl+ywhIh55Q6rwXe0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}