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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '270bc99faf93e5aee65dc349d3732ab0fc054e6bc2de2dbaee187b834a29846f' 
  AND token = 'VCayaFhkvCzJJkD1XLA/b4vOsyj9O+PP+w1dixHs6XU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}