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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f09028ae894400263e39d4a804a402cde472d4210b2c34f51bfecd2ef57f4c1' 
  AND token = 'cY0VKlXHDXOvKuPIGf3PmMNf75wQ7PIMChZ6GmSPOIE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}