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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16294c6f0b08cbadc66a1a47b722e262bc3345b87b0abeb32815a3692f40787f' 
  AND token = 'qdbtsiAMg1oL2yaz3uh/DDOo25KNyCrrNJ1mbeTV52w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}