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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18e08aba7786d01c34229b333b3962b7d5ac0c967284424bbe409de08e2961a8' 
  AND token = 'M/p49gTbv0KWfR/wolgcQPt2MhjgHjdxM46Cm7oUrSA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}