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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e3b46c1802a8f10e1f1d7ad330634ef948cc0648d7ed7d94c405d047982bb881' 
  AND token = 'Ul1mdbe5zheP+x6NIEEsy1O4C9XrQ9/UfHdxSdXfzYI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}