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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '091200ef8ba1be9e7728e8c27f6df3549e57b0bdb5ef3ff09f27606494256052' 
  AND token = 'E3iSSyZ6iSR+uYo7IxWSH392JkUh2LJBoRSDSR1vIC8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}