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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7b81ce9276375387afefa54921908304ff411d45bc0a188e33e2a34173a4ab21' 
  AND token = 'S2bqy6YpmpP+w1sAvPCEMfwgGWrI0qWAUn/gafqp1pQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}