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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '818f06d7ad5cf71a043603629219ac1d97b00bb5d358b5d5a942e49940b5cd78' 
  AND token = 'pon1NjjGiA+7C2eW/NFAg8QUwzC6x+aF4abSo/nCxl0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}