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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c587f78c51e6535dbc4884fbfc36d3def23364dd1d4d399a32cb52a09e51180' 
  AND token = '2UDkybTMyaI3TZ2ngrfAguear+na6QSMZe7B0HxlgS8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}