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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5fb709e0a4342003265fe28ddd356ec2f8521fe748a47c161374575da0453170' 
  AND token = 'R2fTsIUGBrVaI/o1485Gf5UOYfRk0AIttV2IbjrO0Eg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}