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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2f74530e0b3bc16a04be86fe6c29c94054c76d31c4a55c5f213c41a0f1237643' 
  AND token = 'P39MjSlkUdlbCjPUVZTJqGqL86YMAq4AXawMOdFzjnU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}