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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '35bcd3888f845667c7bc2ce05a068e765b4b73513c8b7234d8fc8f19355eba09' 
  AND token = 'dOPm1V5ruSrGoH/4LXVyFEBXuHPigXPOGWCWgXCsMJs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}