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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78ae1051c5cc5f8560592e0820aff2ed05b9873b951fade9f6dbcbd39f83a6da' 
  AND token = 'HMdp0cn3//pNL14Obyv8UR6ZRdPw8iGY4Lor5B64hcM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}