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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21587f782b6fd5b35eb71857c38758ad07f12e7bd533d02c6eba5a657cdffbd6' 
  AND token = '1W0tkOQK5T41C+2aSCVA2mqvjDWcx25Bz3ODZi4hKoo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}