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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12246528f006c9c48f99590e7b7e12b1f8a3c740554a53143b179acba072d416' 
  AND token = 'Nyf9W4PVAYFwaWZE8/0tUZHq4PfAIileUZ/NrB3q0Gs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}